IN VITRO
"...HPV inhibitor even in presence of Nonoxynol 9"
2006-2007
Led by Dr. John Schiller, department head in the Laboratory of Cellular Oncology at NCI, the research team found carrageenan to be a potent inhibitor of HPV infection - the most potent HPV inhibitor in the study (even in the presence of Nonoxynol 9)
IN VIVO
"...Stays active inside a women for over 10 hours"
2015
Led by Albert Einstein College of Medicine (*AECOM*) and Rutgers University Medical School. The results show that Divine 9 stays active inside a woman for over 10 hours, enabling women to dose themselves with Divine 9 before or after a sexual encounter.
Clinical Phase 1
"...93% HPV16 inhibition with median 97.5% decreasing over time"
2015
A phase I clinical study evaluated the inhibition of HPV16 pseudovirons ("HPV16- PsV") with Divine 9, a commercial 2% carrageenan-containing personal lubricant. 93% of the cervicovaginal lavages ("CVL") samples showed HPV16-PsV inhibition with a median of 97.5% decreasing over time.
clinical phase 2
"...36% protective effect vs. placebo"
(Lower compliance due to formula issue)
2021-2023
A 400+ patient base double-blind Randomized Controlled Trial ("RCT") human clinical conducted by McGill University. The carrageenan- based gel was associated with a 36% protective effect compared to the placebo, reducing the risk of both low and high oncogenic risk for genital HPV infections in women. The study was reviewed and published by the Lancet magazine (2023.06)